The main aim of this study was to evaluate the starch acetate as a coat for controlled release microcapsules of glimepiride. Starch acetate based microcapsules were prepared by an emulsion solvent evaporation method employing different core: coat ratios. From in-vitro release studies, it was found that glimepiride release from the microcapsules was slow and spread over a period of 24 h and depended on core: coat ratio, wall thickness and size of microcapsules. Starch acetate was found suitable as microencapsulating agent. Starch acetate coated microcapsules exhibited good controlled release characteristics and were found suitable for oral controlled release of glimepiride over 24 h.
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